The data of the dilution method (minimum inhibitory concentration and minimum bactericidal concentration ) were processed using probit analysis to determine LC50. Materials and Methods: In vitro study that was conducted includes phytochemical test, diffusion, and dilution methods using Meniran extract at 5%, 10%, 20%, and 40% concentrations and tylosin at 2% concentration. This study aimed to determine the activity of Meniran extract (Phyllanthus niruri Linn.) in broilers infected with S. Meniran contributes to inhibiting and antagonizing bacteria and can increase the efficiency of chicken feed because of its bioactive compounds, including alkaloids, flavonoids, tannins, and saponins. Pullorum disease treatment using antibiotics that do not follow the control dose can cause bacteria to become antibiotic-resistant. The result shows that Pisang Ambon’s stem extract reduce significantly in gastric mucosa epithelium erosion and hemorrhagic induced by Indomethacin (p<0.05).īackground and Aim: Pullorum is an acute and chronic disease caused by Salmonella pullorum, often infecting chicken farms. Scoring of mucosa epithelium erosion and hemorrhagic, as qualitative data, was analyzed by Kruskall-Wallis test and continued by using Z test. Each gastric specimen was processed and histopathological changes were observed. Afterwards, they were given Indometachin emultion 5 mg/150 g BW once on 10th day. Positive control (K+) was given 0.5 ml CMC Na 0.5% for 9 days and then given Indomethacin emultion 5 mg/0.5 ml/150 g BW once on 10th day, and the other groups were given Ambon banana stem extract for (P1) 20 mg/150 g BW, (P2) 40 mg/150 g BW and (P3) 80 mg/150 g BW for 9 days. Negative control (K-) was given 0.5 ml CMC Na 0.5 % for 9 days and 0.5 ml corn oil was given on 10th. They were selected randomly and divided into five groups. This research used 30 male rats age 8-12 week having 150 gram weight. sapientum) to prevent gastric damage and observe histopathology of rat’s gastric induced by indomethacin. This research aims to find out the administration effect of Ambon banana stem extract (Musa paradisiaca var.
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